Research environment

INRT 

The Research Cluster Integrative biology: Nuclear dynamics, Regenerative and Translational medicine (RC INRT) is driven by the Institute of Genetic, Molecular and Cellular Biology (IGBMC) that gathers 46 teams and hosts several national & European technology platforms.

This programme explores fundamental mechanisms regulating gene expression, genome stability, cell biology and physiology in normal and pathological conditions. Building on the strengths and interdisciplinarity of IGBMC’s scientific departments in Structural Biology, Functional Genomics, Developmental & cell Biology and Translational Medicine, the program aims at tackling emerging scientific research fields and at developing cutting edge technologies to support research on major questions of fundamental and clinical relevance.

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NetRNA 

The RC NetRNA gathers 15 teams from 3 CNRS units located at the Institute of Molecular and Cellular Biology (IBMC) and the Institute of Plant Molecular Biology. (IBMP). The teams investigate the manifold functions of the non-coding genome across kingdoms, leading to a unique “integrated RNA research institute” in France to study regulatory RNAs and their machineries in infectious diseases offering advanced interdisciplinary and innovative training. The project of NetRNA has evolved to generate an integrated view of the RNA- based strategies developed by pathogens (viruses, bacteria, parasites) and their hosts (plants, insects, mammals) during infection and on the insect strategies to resist viral infection. The consortium is based on shared conceptualization and broad collective expertise and on the use of sophisticated instrumentation.

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MitoCross

The RC MitoCross is constitued by seven teams from three Strasbourg Institutes: the Molecular Genetics, Genomics, Microbiology (GMGM), the Institute of Plant Molecular Biology (IBMP) and the CRBS, working on various aspects of mitochondrial research. They are also implicated in aging, incurable neuromuscular diseases & common pathologies such as Alzheimer’s disease or some cases of cancer and diabetes. The MitoCross aim is to deepen the knowledge of the molecular mechanisms governing mitochondrial biogenesis, genetics and cross-talk with the nucleus and to exploit this knowledge to understand biochemical mechanisms of mitochondrial dysfunctions, to envision agronomic applications and innovative therapies.

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HepSYS

THE RC HepSYS consists of a team of highly qualified molecular biologists, cellular scientists, bioinformaticians, hepatologists and liver surgeons from the institute of Viral and Liver Disease (Unistra, Inserm Unit U1110)), and the University Hospital of Strasbourg (HUS). A key strength of the LabEx is the full integration of basic, translational and clinical research, along with strong collaborations and networks of excellence with experts from the field at the national and international level. Since its creation in 2011, HepSYS has made major contributions to the field supported by a long- standing track record in the understanding of viral and metabolic pathogenesis of liver disease and their translation into clinical applications including the development of novel preventive and therapeutic strategies.

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