The integrative biology: Nuclear dynamics, Regenerative and Translational medicine (RC INRT) is based on the four departments of the IGBMC
Patrick Schultz, Director of the IGBMC and coordinator of the INRT
IGBMC Department of Translational medecine & Neurogenetics biology
Modelling human diseases to explain the main mechanisms implicated in the functioning of the nerve system and understand the molecular mechanisms responsible for the genetic diseases that affect the nerve system and the muscles
Nicolas Charlet-Berguerand, Director of the Department
IGBMC Department of Functional genomics
& Cancer
Deciphering the fundamental mechanisms governing genome expression and preservation in normal and pathological contexts
Frédéric Coin, Director of the department
IGBMC Department of Integrated Structural biology
Mechanisms of gene expression, drug structure : understanding the fundamental mechanisms regulating the expression of genetic information in messenger RNA and protein
Valérie Lamour, Director of the Department
IGBMC Department of Developmental & Stem cell biology
From cellular plasticity to regenerative medicine: we study the fate and reprogramming of embryonic and adult cells as well as the signals and mechanisms that allow an organ to take its shape and function
Manuel Mendoza, Director of the Department
Outside departments
IGBMC Department of Translational medecine & Neurogenetics biology – TEAMS
Headed by Nicolas Charlet-Berguerand
nicolas.charlet-berguerand@igbmc.fr
RNA diseases
Study human genetic diseases due to expansions of tri-, tetra- or penta-nucleotide repetitions that are located in the so-called «non-coding» regions of the genome, mainly : myotonic dystrophy, tremor and ataxia syndrome associated with fragile X and amyotrophic lateral sclerosis.
Headed by Yann Hérault
yann.herault@igbmc.fr
Physiopathology of aneuploidy, gene dosage effect & Down syndrome
Better understand the physiopathology of aneuploidies and other genetic diseases with Intellectual Disabilities, using mouse and rat models. Explore behaviour and cognition in models of other intellectual disabilities of genetic origin.
Headed by Jocelyn Laporte
jocelyn.laporte@igbmc.fr
Muscle and diseases
Identify the genetic basis and better understand the mechanism of neuromuscular diseases (neuropathies and myopathies) through multi-omics and big data approaches, and validate therapeutic proof-of-concepts with gene modulation and pharmacology.
Headed by Juliette Godin
juliette.godin@igbmc.fr
Regulation of cortical development in health & disease
Our labs aims to elucidate the fundamental mechanisms that dictate cell fate acquisition and neuronal maturation during mammalian corticogenesis. Our main interests are : (i) Understand the origin of neuronal diversity in the mouse developing cortex; (ii) Study post-transcriptional mechanisms that regulate gene expression during cerebral cortex neurogenesis; (iii) Interpret the pathological mechanisms of associated neurodevelopmental disorders; and (iv) Understand the sensitivity of the brain to tRNAs defects.
Headed by Christelle Golzio
christelle.golzio@igbmc.fr
Study of copy number variants in autism spectrum disorders & their commorbidities
Understand how genetic variation can impact the development and homeostasis of the nervous system thanks to developed animal and IPSCderived models to study the impact of gene dosage defects on basis neurodevelopmental processes to: Discover genes and alleles that contribute to disease; Capture and validate genetic interactions and Identify genes implicated in autism spectrum disorders associated comorbidities.
Headed by Amélie Piton & Hervé Moine
piton@igbmc.fr
moine@igbmc.fr
Genetics and pathophysiology of neurodevelopmental Disorders
Identify novel genes and molecular mechanisms involved in neurodevelopmental and neurological disorders using omics approaches and pertinent 2D (human neural stem cells, cortical neurons) and 3D (brain ogranoids) cellular models. Dissecting the pathophysiological mechanisms involved in Fragile-X syndrome and develop gene therapy using mouse models.
IGBMC Department of Functional genomics
& Cancer – TEAMS
Headed by Elisa Bergamin
elisa.bergamin@igbmc.fr
Structural & functionnal basis of chromatin remodelling
Understand the mSWI/SNF complex at the molecular and atomic level through the combination of electron cryomicroscopy, X-ray crystallography molecular biology and biochemistry.
Headed by Frédéric Coin
frederic.coin@igbmc.fr
Genome expression & repair
Study the mechanisms of aging and cancer in various cellular systems and animal models that are deficient in DNA repair and transcription, by using biochemistry, genetics and cell biology.
Headed by Irwin Davidson
irwin.davidson@igbmc.fr
Regulation of gene expression in cancer
Study how transcription factors and their co-factors such as chromatin remodeling complexes regulate gene expression during development, in physiological processes, oncogenic transformation and tumor progression, through high throughput genomics and at the single cell level.
Headed by Angela Giangrande & Pierre Cattenoz
angela.giangrande@igbmc.fr cattenoz@igbmc
Immune & neural development
Understand how cell diversity is generated and how cells interact to build the highly complex architecture of pluricellular organisms. Study the molecular and the epigenetic events controlling cell differenciation and reprogramming.
Headed by Ali Hamiche
ali.hamiche@igbmc.fr
Chromatin & epigenetic regulation
Investigate the role of histone variants and their deposition mechanism in epigenetic control of human genome activity, including the role of histone variants in gene regulation and genome
Headed by Susan Chan & Philippe Kastner
susan.chan@igbmc.fr
philippe.kastner@igbmc.fr
Hematopoiesis & leukemogenesis in the mouse
Investigate how transcription factors control the development of hematopoietic stem cells into pluripotent progenitor cells and then into mature blood cells, a process called hematopoiesis. Understand how altering the function of transcription factors contributes to malignant cell formation.
Headed by Mei Li
mei.li@igbmc.fr
Pathogenesis of inflammatory diseases
Decode the complex molecular and cellular networks driven by epithelium-derived cytokines such as thymic stromal lymphopoietin (TSLP) during inflammatory responses, determine the function of these networks in the pathogenesis of inflammatory diseases, notably atopic diseases and cancer, and translate the acquired knowledge into new biomarkers and therapeutic strategies.
Headed by Norbert Ghyselinck
norbert.ghyselinck@igbmc.fr
Pathophysiology of vitamin A signaling pathways
Combine innovative genetic, pharmacological and molecular approaches in mouse to study the cellular and molecular mechanisms underlying the ability of retinoic acid, the active metabolite of vitamin A to promote the differenciation in vivo, using cells as a model system.
Headed by Gabriel Malouf
maloufg@igbmc.fr
Molecular & Translational Oncology
Unravel the molecular underpinnings of kidney and rare cancers through comprehensive multi-omics analysis, encompassing single-cell and spatial transcriptomics, functional genomics, and murine modeling. The aim is to uncover novel therapeutic targets and treatment strategies.
Headed by Daniel Metzger
daniel.metzger@igbmc.fr
Pathophysiological function of nuclear receptor signaling
Study, under physiological and pathophysiological conditions, the functions and interdependence of signaling pathways that are regulated by various nuclear receptors in different organs.
Headed by Raphaël Pantier
raphael.pantier@igbmc.fr
Genomic and epigenomic regulation of cell fate
Uncover the molecular mechanisms underlying the action of transcription factors and epigenetic regulators in stem cells using a combination of genetic engineering, biochemical assays and multi-omics technologies. Our overall goal is to improve our understanding of the regulation of cell identity in physiological and pathological conditions.
Headed by Thomas Sexton
thomas.sexton@igbmc.fr
Spatial organization of the genome
Determine if and how chromosome folding can influence transcription. To show how gene programs can be co-ordinately regulated or lead to diseases such as cancer, and also provide tools for gene therapy.
Headed by Catherine-Laure Tomasetto
catherine-laure.tomasetto@igbmc.fr
Molecular & cellular biology of breast cancer
Understand at the molecular level the role of the mesenchymal factor, MMP11, in the progression of breast cancers. Characterize the function of genes amplified in breast cancer cells.
Headed by Anaïs Bardet
bardeta@igbmc.fr
Computational regulatory genomics
Understand how transcription factors bind to specific DNA sequence motifs in the genome to regulate gene expression, how DNA methylation affects transcription factor binding and how their misregulation is implicated in cancer.
Headed by Stéphane D. Vincent
stephane.vincent@igbmc.fr
Transcription complexes in development and disease
Explore and characterize the variability existing in vivo, in the protein complexes involved in RNA polymerase II transcription initiation. Evaluate its importance during development and differentiation. Understand how human mutations affecting subunits of these complexes can lead to human disease.
IGBMC Department of Integrated Structural biology – TEAMS
Headed by Helgo Schmidt
helgo.schmidt@igbmc.fr
Structural biology of molecular machines
Combine cryoelectron microscopy and x-ray crystallography to elucidate how the microtubule motor dynein and the structurally related ribosome maturation Rea1 produce force to power movement along microtubules and facilitate ribosome maturation.
Headed by Annick Dejaegere
annick.dejaegere@igbmc.fr
Chemical biophysics of transcriptional signaling
Combine biophysical experiments (x-ray crystallography, cryo-EM, SAXS, mass spectrometry, ITC) and numerical simulations (molecular dynamics simulations) to understand how chemical signals (ligands, post-translational modifications) affect the structure and dynamics of protein and protein-DNA complexes and how these changes are implicated in their regulation.
Headed by Mikhail Eltsov
mikhail.eltsov@igbmc.fr
Biomolecular condensation in nuclear organization & function
How are 2m of DNA packed into each cell nucleus into our body? We combine cryogenic optical microscopy and electron tomography to understand chromatin condensation and its role in regulating gene expression and maintaining genome stability.
Headed by Bruno Kieffer
bruno.kieffer@igbmc.fr
Nuclear magnetic resonance, molecular complexity & dynamics
Characterize and study the relevant molecular properties which achieve a given biological function by combining multi-scale experimental and modeling approaches (from the atom to the cell). Develop numerical methods adapted to massive data analysis. Apply these approaches to developing new therapeutic strategies for prostate cancer.
Headed by Clément Charenton
charentc@igbmc.fr
mRNA processing
Study complex molecular machines that modify messenger RNAs to create valid templates for protein synthesis. Use biochemistry to capture these elusive multisubunit enzymes from their native environment and cryo-EM to obtain structural “snapshots” of their precise mechanisms of action.
Headed by Bruno Klaholz
bruno.klaholz@igbmc.fr
Large complexes involved in gene expression
Analyze the molecular mechanism of action of the bacterial and human ribosome, nucleoprotein complexes and viruses in different structural and functionnal states or with inhibitors, through integrated structural biology including biochemistry, X-ray crystallography, high-resolution cryo-EM and electron tomography.
Headed by Christophe Romier
christophe.romier@igbmc.fr
Molecular basis of chromatin & transcription regulation
Determine, at the molecular and structural level, epigenetic mechanisms, to discover how they regulate the organization of chromatin and nuclear mechanisms, and to understand their involvement in many diseases.
Headed by Adam Ben Shem& Gabor Papai (photo)
adam@igbmc.fr
papai@igbmc.fr
Architecture of nucleoprotein systems by 3D electron microscopy
Decipher the three-dimensional organization and understand the functioning of molecular nanomachines involved in gene expression regulation and chromatin structure using electron cryomicroscopy to visualize isolated molecules in their native state.
Headed by Gilles Travé
gilles.trave@igbmc.fr
Viral oncoproteins & domain-motif networks
Study viral oncoproteins (cancer-causing proteins) to describe the subversion of cellular functions by oncogenic viruses by generating quantitative and exhaustive information at two levels of analysis : atomic and interactomic.
Headed by Albert Weixlbaumer
albert.weixlbaumer@igbmc.fr
Regulation of transcription
We use biochemistry and structural biology to study transcription by RNA polymerase (RNAP). We aim to understand how RNAP is regulated and organized in supramolecular assemblies with other enzymes. These higher order complexes give rise to new functions difficult to deduce from studies of the individual components.
Headed by Valérie lamour
valerie.lamour@igbmc.fr
Regulation of DNA topology
Our goal is to decipher the molecular mechanisms that govern the transport, processing, and topological rearrangements of nucleic acids. We focus on understanding the molecular architecture of nucleoprotein complexes that include key drug targets, such as bacterial and human DNA topoisomerases and retroviral integrase. To achieve this, we combine advanced structural techniques, including cryo-electron microscopy, with functional data.
Headed by Florian Faessler
florian.faessler@igbmc.fr
Cellular architecture
Delve into the native (ultra-)structure of the cytoskeleton, scaffolding proteins, and tethers employing cryo-focused-ion beam milling, cryo-electron tomography, and subtomogram averaging. Integrate those insights with the results from cell biology and biochemistry approaches to learn how cells establish and maintain their internal organization
Headed by Gulnara Yusupova
gulnara.yusupova@igbmc.fr
Molecular basis for protein synthesis by the ribosome
Acquire new structural knowledge on the mechanism of ribosome protein synthesis and the mode of action of ribosome inhibitors. Study X-ray and cryo-EM structures and mechanism of protein biosynthesis in bacteria, yeasts and humans, a process carried out by a large ribonucleoprotein complex : the ribosome.
IGBMC Department of Developmental & Stem cell biology – TEAMS
Headed by Wojciech Krezel
krezel@igbmc.fr
Brain development & physiology
Understanding the role of certain signals includingthose mediated by Vitamin A (retinoic acid) and its receivers during development and brain neurogenesis, and for the efficient functionning of neuron populations.
Headed by Gérard Gradwohl
gerard.gradwohl@igbmc.fr
Differentiation & physiopathology of endocrine cells in the pancreas & intestine
Study the mechanisms that control cellular destiny, intestinal endocrine cells identity in normal and pathological situations such as diabetes.
Headed by Minchul Kim
minchul.kim@igbmc.fr
Syncytial cell biology
Understanding how the unique cellular anatomy of syncytial cells affects their function in health and disease using the skeletalmuscle as a paradigm. We currently explore the role and mechanism of diverse nuclear identities in muscle cells.
Headed by Bill Keyes
bill.keyes@igbmc.fr
Common mechanisms of development, cancer & aging
Investigating how cellular senescence contributes to development and regeneration, and how its misregulation contributes to aging and diseases such as cancer and neurodegeneration.
Headed by Manuel Mendoza
manuel.mendoza@igbmc.fr
Nuclear organization & division
Study cell division and differentiation, with a focus on how nuclear structures are reorganised in time and space during cell proliferation.
Headed by Bernardo Reina San Martin
bernardo.reina-san-martin@igbmc.fr
Molecular biology of B cells
Study molecular mechanisms driving antibody diversification, with a specific focus on the protein complexes involved in mediating AID targeting and in repairing AID-induced DNA damage in vivo
Headed by Roméo Ricci
romeo.ricci@igbmc.fr
Signal transduction in metabolism & inflammation
Discover and understand the signaling axes of inflammation involving protein kinases and likely to have an important role in the mechanism of inflammation.
Headed by Daniel Riveline
daniel.riveline@igbmc.fr
Cell physics
Understand cellular motility and division as well as the shape of cells in tissues, by studying the dynamics of the cytoskeleton and the associated Rho signalling pathways.
Headed by Izabella Sumara
izabella.sumara@igbmc.fr
Cell cycle & ubiquitin signaling
Ubiquitin-mediated control of cell division in health and disease.
Headed by Sophie Jarriault
sophie.jarriault@igbmc.fr
Cellular plasticity & direct reprogramming in C. elegans
Cellular reprogramming : Combining Imaging, Genetics incl. CRISPR-Cas9, Molecular Biology and Transcriptomic tools to decipher the mechanisms that make specific cells naturally able to change their identity, at the single cell level; steps, positive & negative regulators, impact of extrinsic cues and the intrinsic context, environmental influence, importance of epigenetic processes for the invariance, or the cellular trajectory taken during the transition
Headed by Anne-Cécile Reymann
anne-cecile.reymann@igbmc.fr
Actin dynamics & biomechanics of the early embryo
Study of the actin cytoskeleton in C. elegans, notably its dynamics and mechanical properties. We are currently exploring the molecular to functional consequences of actin variants reproducing nonmuscle actinopathies, a set of human rare diseases.
Outside departments teams
Headed by Bertrand Séraphin
bertrand.seraphin@igbmc.fr
Eukaryotic mRNA decay
Understand how mRNA decay contribute to regulated gene expression and how these mechanisms are affected in some pathologies including cancer, specific genetic diseases as well as during viral infections. Elucidate the mechanisms coordinating mRNA decay with transcription and translation.