Unravelling the cell circuits of liver disease and cancer: an innovative integrative research program to uncover novel therapeutic strategies for prevention and treatment of liver disease and associated cancer. By integrating basic, translational and clinical research, our program aims at translating our findings and compounds into clinical applications.
Thomas Baumert, coordinator of HepSYS
Headed by Thomas Baumert
thomas.baumert@unistra.fr
Unravelling the cell circuits of liver disease and cancer to discover novel therapeutic targets
Chronic liver disease and cancer are key challenges of public health with unsatisfactory treatment options. Using a recently established single cell RNASeq pipeline, combined with advanced proteomics, patient – derived cell culture and animal models, we aim to understand the cell circuits of virus – induced and metabolic liver cancer. The understanding of disease biology on a molecular level, enables us to uncover novel targets and componounds for treatment. A unique hallmark of our program is the integration of laboratory studies with patient data using advanced computational analyses.