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Welcome to our new PhD students -Part III

Third week to go! this week we present the portraits of Yash, from India, and Thomas, from France.

Research Cluster INRT – Department of Development and Stem Cells, Yash Parekh

After finishing his Master’s from NIT, Bhopal, India, Yash joined the Centre for Cellular and Molecular Biology as a Project Associate. Being majorly exposed to translational research, he worked on the development of the 3D bioprinted cornea and was also actively involved in establishing the culture systems for various SARS-CoV2 strains.

In October 2022, he embarked upon his PhD journey under the mentorship of Dr Wojciech Krezel and Dr Pascal Dolle as part of the IMCBio International PhD program. His work revolves around the framework of the “Integrative Biology: Nuclear dynamics, Regenerative and Translational medicine” (INRT) research cluster. His research focuses on deciphering the role of retinoid receptors in the microglial and oligodendrocyte development

Moving to a new country was for Yash a big decision and he is glad his first international experience is in Strasbourg. The city has brought in many new experiences in his life and he states cooking as his upcoming talent.

Yash describes himself as calm, quiet and an ambivert. Apart from spending time in the lab, he loves to indulge in watching movies and is a big Bollywood and MCU fan.

His motivation to join IGBMC stems from his previous work experience and also from the excitement of getting a chance to work in an interdisciplinary and interactive environment and working alongside a very positive mentorship.

Research Cluster NetRNA at ARN-Unit, IBMC – Thomas Morand

After obtaining a degree in sociology in his native city of Nantes and spending a year as an Erasmus exchange student in Lund, Sweden, rich in experiences and discoveries, Thomas Morand decided to reorient himself towards the discipline that had attracted him for many years – biology – with the objective of doing scientific research. He followed a bachelor’s degree in molecular and cellular biology in Nantes, then decided to apply for the master’s degree in Biology and Molecular Genetics in Strasbourg associated to the IMCBio program. His choice was motivated by the reputation of the “Eurometropole” in terms of teaching and research in life sciences, but also by the living environment offered by the beautiful city of Strasbourg. As part of his master’s degree, he had the opportunity to do internships at the IGBMC and at the IBMC, which gave him a good overview of the research as a profession.

After his master, he joined Pr Carine Meignin’s team as a PhD Student in the IMCBio PhD program to study the epitranscriptome of viral RNAs and its role in viral replication using Drosophila melanogaster as a model, an innovative and under-explored subject.

He was attracted by the PhD subject which he finds exciting, by the seriousness of the research unit and the host team, as well as the reputation of the IBMC and the IMCBio program. His work will take place in the framework of the NetRNA research cluster.

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Welcome to our new PhD students 2022-2023 – Part II

This week we have the portraits of Solène, from France, and Brian from Mexico.

Research Cluster MitoCross at GMGM – Solène Zuttion

to biology and research, Solène Zuttion has just been recruited by the IMCBio Graduate School and enrolled in its PhD track with the support the Research Cluster MitoCross.

After a BSc in molecular and cellular biology, she completed a MSc degree in Molecular Biology and Genetics in Strasbourg with the dream of doing a PhD and becoming a research scientist. All along her university course, she did a lot of research internships. But it was during her first internship at the Institut de Physiologie et de Chimie Biologique (IPCB) that she became passionate about the intracellular trafficking of proteins (team of Dr. Sylvie Friant) and discovered the aminoacyl-tRNA synthetases world main subject of Prof. Hubert Becker’s research. She joyfully combines today the expertise of each team by working under their co-direction on the control of the Tor pathway by organellar echoforms of cytosolic aminoacyl-tRNA synthetases.

Aminoacyl-tRNA synthetases are enzymes that catalyze the synthesis of the aminoacyl-tRNA. Enabling the decoding of the messenger RNA codons in all living organisms, aminoacyl-tRNAs and aminoacyl-tRNA synthetases are cornerstone components of the protein synthesis machinery. However, aminoacyl-tRNA synthetases can also be post-translationally modified allowing them to relocate from the cytoplasm (location of protein synthesis) to a wide range of different cellular organelles to fulfil numerous uncanonical functions such as regulation of inflammatory response, autophagy, or regulation of the target of rapamycin complex 1 (TORC1) as it is the case for leucyl-tRNA synthetase (Figure 1). Pivotal regulator of cell growth and metabolism, TORC1 is mainly located at the vacuole as well as on the surface of late endosomes where it stimulates protein, lipid, and nucleotide synthesis by phosphorylating numerous protein targets. Dysregulated in cancers, the molecular mechanisms allowing its activation and inactivation are still poorly understood and Solène’s PhD research project aims to elucidate how organellar echoforms of cytosolic aminoacyl-tRNA synthetase can relay the nutritional sensing to the TOR kinase.

Figure 1. Adapted from Bonfils et al., 2012
(Cartoon by Marine Hemmerlé)

Research Cluster INRT – Department of Integrative and Structural Biology, Brian Lopez

Brian Lopez Duran completed his studies in Biology at UNAM (Autonomous National University of Mexico). He followed his training with a master’s degree in biochemistry at Alfredo Torres Larios’ group, which he considers his most significant step. Throughout these two years, he discovered his passion for Structural Biology. It was common in his lab to be involved in different projects, but his efforts were focused on RNase P, a ribonucleoprotein complex that represents an attractive target for the development of antibiotics. In this challenging project, he explored different areas of the x-ray crystallography and bioinformatic analysis of biomolecules. After numerous attempts to obtain PhD financing, he got the opportunity to continue his training at IMCBio Graduate School under the supervision of Dr. Valerie Lamour.

On the reason for choosing IGBMC/IMCBio for his PhD, Brian says: “There are many reasons for me wanting to join the program. In general, I am deeply interested in the study of nuclei acid complexes from a structural approach. Secondly, I believe that IGBMC through the Structural and Integrative Biology Department has the potential and the resources to develop high-impact research and explore very interesting research questions. A common approach is to analyse the individual components of enormous macromolecular machines, but these elements are not isolated. Techniques like Cryo-EM open the possibility to ask more complex questions about biomolecules in the native cell environment. I would like to help in the search for answers to these questions”. 

Brian (left) with research colleagues in Mexico (image by A. Torres)
Figure 1 RNase P with P protein interacting with pre-tRNA, PDB: 6MAX (image: Torres, Madrigal – modified by Brian Lopez)
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Welcome to IMCBio – PhD students 2022-2023

A portrait of our newly minted IMCBio PhD researchers

After two stimulating rounds of PhD applicant interviews in the late Spring – early Summer, we are welcoming in Strasbourg the new IMCBio PhD students. Eleven young researchers from 5 different countries and 3 different continents are starting their PhD within the IMCBio program this Fall.

Each week we will present in this section two brief biographies of these new IMCBio colleagues, in order to introduce them to the IMCBio community. Make sure to keep an eye on our news posts!

Rishabh Kapoor – Gérard Gradwohl’s team, IGBMC

Rishabh Kapoor is a student from New Delhi, India. He completed his master’s in Biotechnology and further on joined National Brain Research Centre to work on Neurotropic Viruses and Primary human Neural Stem cells. After getting a second authorship in a recently published research article, his keen interest in Stem cell biology inspired him to apply for the opportunity offered by the IMCBio Programme and work in the field of developmental biology.

He joined Dr Gérard Gradwohl’s team as a PhD student to work on deciphering new transcription factors involved in the development of mature and functional iPSC-derived pancreatic beta cells and determining their role. His work will take place in the framework of the “Integrative biology: Nuclear dynamics, Regenerative and Translational medicine” (INRT) Research Cluster.

Football has always been a keen interest of Rishabh, together with cooking and E-sports. Rishabh chose to join IGBMC and IMCBio program due to its attractiveness and ease of accommodating and integrating international students. Multi-disciplinary teams and various technological platforms made IGBMC an attractive choice for a young budding researcher. The Red-Carpet package also facilitated his travel and installation in Strasbourg, which is an important aspect for an international student.


Grégory Renard – Anne-Marie Duchêne’s and Laurence Drouard’s Team, IBMP

Grégory Renard joined the University of Strasbourg in 2018 to take a bachelor’s degree in Molecular and Cellular Biology, and then a master’s degree in Genetics and Molecular Biology in the framework of the IMCBio Program at the Master level. The program allowed him to perform 3 different internships during his 2-year Master degree and to decide to pursue his career in a PhD program. His interest in the world of scientific research, and mainly in molecular biology studies conducted in Strasbourg, encouraged him to join the IMCBio PhD program to have the opportunity to work in this field.

He joined the team of Pr. Anne-Marie Duchêne and Pr. Laurence Drouard (Institut de Biologie Moléculaire des Plantes, IBMP) in 2022 as a PhD student and will work on the mechanisms behind mitophagy in plant cells and the protein network involved in this pathway. At IBMP, Grégory will benefit from high-end expertise in molecular biology to uncover all the secrets of this incompletely understood, yet essential mechanism of plant cells. His work is placed in the framework of the “Crosstalk of mitochondria and the rest of the cell, mitochondrial functions & dysfunctions” (MitoCross) Research Cluster.

His choice of the IMCBio PhD program was mostly based on his experience with the research teams based in Strasbourg during his studies. This program will allow him to have complete and transdisciplinary training in different scientific fields to prepare himself to take part in the scientific research of tomorrow.

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Thank you all for a successful Master Day 2022!!

On Friday, September 2nd, 2022, IMCBio hosted 140 guests in the fourth edition of IMCBio’s Master Day.  The introduction to IMCBio by the programs’ director, Bertrand Séraphin, for the M1 freshmen of the IMCBio associated master specialities (Faculty of Life Sciences, Strasbourg University), was followed by stimulating graphical abstract presentations by newly promoted IMCBio M2 students, on the research projects they performed during their summer internships. The audience, together with members of the IMCBio Master and Executive committees, assured lively discussions. The weather was on our side: all participants could enjoy lunch provided by the IMCBio graduate school in the IGBMC garden. Coffee breaks together with the Poster session offered opportunities to everyone for scientific exchange. Directors of the Research Clusters (LabEx) at the basis of IMCBio (or their representatives) presented their research axes in the afternoon encouraging M1 students to join our graduate school.

We would like to thank all participants, as well as the staff of IGBMC and administrative assistants to the EUR for their support in making this event possible.

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IMCBio’s Master Day 2022 – Save the date! September 2nd

We are glad to announce the IMCBio Master Day 2022, which will be the starting point for Master-level recruitment in the IMCBio Graduate School. This day aligns with the French tradition of the “rentrée”. This year the IMCBio Master Day will take place on September 2, 2022 at the IGBMC in Illkirch. We propose a stimulating program for both Master 1 and Master 2 students. The Day will start with a presentation of the IMCBio Graduate School by its directors. Dynamic presentations of summer internships by our M2 students will proceed in a graphical abstract format. During the lunch break, posters will offer opportunities to discuss with IMCBio researchers of ongoing projects and possibilities for internships in one of the IMCBio areas:

Development and stem cells

Functional genomics and cancer

Integrated structural biology

Translational medicine and neurogenetics

Networks of regulatory RNAs

Mitochondrial function and dysfunction

Viral hepatitis and liver diseases

We look forward to welcoming you to the IMCBio Master Day!